![]() ![]() Diseñoġ) Se realizó una búsqueda sistemática en las bases de datos Medline, Stabilis, Handbook on Injectable Drugs y Micromedex, para completar y actualizar la información disponible. Recopilar la información publicada sobre estabilidad de los fármacos usados en el paciente crítico, evaluar la calidad de los datos publicados y generar una tabla de compatibilidad con información actualizada. The study contributes to the safe administration of intravenous drugs in critical patients with a view to avoiding adverse events in this frail population. This review provides new reliable evidence about the physicochemical stability of drugs commonly used in the critical care setting. Accordingly, drug stability knowledge was available for 50.3% of the studied admixtures, in which 77.1% of the binary combinations proved compatible and 16.8% proved incompatible. However, 93% guaranteed correct reproducibility. None of the included studies followed all the methodological requirements. The systematic review included 29 studies (27 originals, 2 reviews). (iii) A compatibility table was produced with data for 44 binary combinations of drugs frequently used in the ICU. (ii) Article quality was analyzed according to the stability studies practice guidelines. Articles published from 1990 to 2017 in English, Spanish and French were included. (i) A systematic review was conducted searching the following databases: Medline, Stabilis, Handbook of Injectable Drugs and Micromedex. To gather all published information about the stability of drugs commonly used in Intensive Care Units (ICU) evaluate the methodology of published data and generate a compatibility table.
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